… The tendency of prostate cancer to develop multifocally has … an individual gland, the possibility
that spatially separate tumors may … of clinical outcome may truly reflect or predict the true …

… BRCA2 genes are associated with ~60–90% probability of … type, but instead relied solely on
a molecular marker: indeed, an anti-… , it is still clinically significant to predict good response to …

… multigene predictor is in late stage clinical development 12 … procedures designed to predict
outcome in breast cancer … low risk have a higher likelihood of metastasis-free survival than …

… chance and a challenge creating the new field of predictive … and also defining clusters of
genes predicting clinical outcome… Based on several clinical studies three molecular markers—…

… neoplastic evolution or the same molecular markers existing … genetic and pharmacologic
data from multiregional cancer … tumor staging, prognostic prediction, and treatment allocation…

… genetic changes resulting in no clinical growth. In inherited … known cancer risk) result in
increased probability of critical genetic … Indeed, this prediction is supported by a recent study that …

… Cancer prognosis is the prediction of the evolution of the disease. Knowing the prognosis
is key to estimating the probability of cancer … In each case, we have identified the type of …

… 6] presupposes that cancer develops from multifocal areas of … [7,[11], implying that molecular
markers have the potential to … markers for prediction of therapeutic outcomes in colorectal …

… The addition of molecular markers is an improvement over … ], was used to develop a
regression model to predict low risk … them to the TCGA dataset to obtain a predicted probability of …

… recurrence in patients with unifocal versus multifocal disease … A 17-gene GPS algorithm
was developed from the 58 genes … , we compared the predicted probability versus observed …