COMPARATIVE EFFICACY OF SULPHUR-CONTAINING AMINO ACIDS DERIVATIVES IN ACUTE KIDNEY INJUTY OF VARIOUS ETIOLOGY
DOI:
https://doi.org/10.30888/2663-5712.2025-32-02-034Ключові слова:
nephroprotective activity, ademetionine, ischemia-reperfusion kidney injury, gentamicin-induced nephropathyАнотація
This experimental study investigated the nephroprotective potential of sulfur-containing amino acids (SCAA) - ademetionine, taurine, and glutathione, under various models of acute kidney injury (AKI), including ischemia-reperfusion injury, rhabdomyolysis,Metrics
Посилання
Hoste, E.-A. J., Kellum, J. A., Selby, N. M., Zarbock, A., Palevsky, P. M., Bagshaw, S. M., ... & Mehta, R. L. (2018). Global epidemiology and outcomes of acute kidney injury. Nature Reviews Nephrology, 14(10), 607–625. https://doi.org/10.1038/s41581-018-0052-0
Tang, L., Wang, B., Li, J., Song, H., & Zhou, Y. (2021). Hypoxia-preconditioned mesenchymal stem cells enhance autophagy in tubular epithelial cells and attenuate renal ischemia–reperfusion injury. Stem Cell Research & Therapy, 12(1), 328. https://doi.org/10.1186/s13287-021-02374-x
Zhang, H., Wang, X., Wang, J., Liu, L., Li, J., Yang, X., ... & Zhang, C. (2024). Liproxstatin-1 protects against ferroptosis to mitigate acute kidney injury in ischemia-reperfusion models. Antioxidants, 13(2), 182. https://doi.org/10.3390/antiox13020182
Tonnus, W., & Linkermann, A. (2020). Ferroptosis in kidney injury and disease. Frontiers in Cell and Developmental Biology, 8, 479. https://doi.org/10.3389/fcell.2020.00479
Sarwar, S., Hossain, M. J., Irfan, N. M., Ahsan, T., Arefin, M. S., Rahman, A., ... & Rahman, M. M. (2022). Renoprotection of selected antioxidant-rich foods (water spinach and red grape) and probiotics in gentamicin-induced nephrotoxicity and oxidative stress in rats. Life, 12(1), 60. https://doi.org/10.3390/life12010060
Babaeenezhad, E., Dezfoulian, O., Hadipour Moradi, F., Rahimi Monfared, S., Fattahi, M. D., Nasri, M., Aminic, A., & Ahmadvand, H. (2023). Exogenous glutathione protects against gentamicin-induced acute kidney injury by inhibiting NF-κB pathway, oxidative stress, and apoptosis and regulating PCNA. Drug and Chemical Toxicology, 46(3), 441–450. https://doi.org/10.1080/01480545.2022.2049290
Rezaie, A., Nasri, H., Baradaran, A., & Rafieian-Kopaei, M. (2020). Immunomodulatory and antioxidant effects of taurine: Possible role in prevention of chronic kidney disease. Iranian Journal of Kidney Diseases, 14(5), 339–347. https://pubmed.ncbi.nlm.nih.gov/32996850/
Singh, A. P., Junemann, A., Muthuraman, A., Jaggi, A. S., Singh, N., Grover, K., & Dhawan, R. (2012). Animal models of acute renal failure. Pharmacological Reports, 64, 31–44.
Albukhari, T. A., Bagadood, R. M., Bokhari, B. T., Filimban, W. A., Sembawa, H., Nasreldin, N., ... & Ahmad, A. (2025). Chrysin attenuates gentamicin-induced renal injury in rats through modulation of oxidative damage and inflammation via regulation of Nrf2/AKT and NF-κB/KIM-1 pathways. Biomedicines, 13(2), 271. https://doi.org/10.3390/biomedicines13020271
Sabra, M. S., Allam, E. A. H., El-Aal, M. A., & Mohamed, E. (2025). A novel pharmacological strategy using nanoparticles with glutathione and virgin coconut oil to treat gentamicin-induced acute renal failure in rats. Naunyn-Schmiedeberg’s Archives of Pharmacology, 398, 933–950. https://doi.org/10.1007/s00210-024-03303-4
Nadeem, R. I., Aboutaleb, A. S., Younis, N. S., & Ahmed, H. I. (2023). Diosmin mitigates gentamicin-induced nephrotoxicity in rats: Insights on miR‑21 and ‑155 expression, Nrf2/HO‑1 and p38‑MAPK/NF‑κB pathways. Toxics, 11(1), 48. https://doi.org/10.3390/toxics11010048
Wu, H., Wu, Y., Li, J., & Li, C. (2021). Recent advances in pharmacological treatment of acute kidney injury: Focus on ferroptosis and oxidative stress. Acta Pharmacologica Sinica, 42, 1571–1582. https://doi.org/10.1038/s41401-021-00682-2
Опубліковано
Як цитувати
Номер
Розділ
Ліцензія
Авторське право (c) 2025 Автори
Ця робота ліцензується відповідно до Creative Commons Attribution 4.0 International License.
